Energy Landscape Reveals the Underlying Mechanism of Cancer-Adipose Conversion in Gene Network Models.

ABSTRACT: Cancer is a systemic heterogeneous disease involving complex molecular networks. Tumor formation involves an epithelial-mesenchymal transition (EMT), which promotes both metastasis and plasticity of cancer cells. Recent experiments have proposed that cancer cells can be transformed into adipocytes via a combination of drugs. However, the underlying mechanisms for how these drugs work, from a molecular network perspective, remain elusive. To reveal the mechanism of cancer-adipose conversion (CAC), this study adopts a systems biology approach by combing mathematical modeling and molecular experiments, based on underlying molecular regulatory networks. Four types of attractors are identified, corresponding to epithelial (E), mesenchymal (M), adipose (A) and partial/intermediate EMT (P) cell s

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11538663 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature