Integrative genomic analysis of RNA-modification-single nucleotide polymorphisms associated with kidney function.

ABSTRACT:

Introduction

Increasing evidence suggests that RNA modification plays a significant role in the kidney and may be an ideal target for the treatment of kidney diseases. However, the specific mechanisms underlying RNA modifications in the pathogenesis of kidney disease remain unclear. Genome-wide association studies (GWAS) have identified numerous genetic loci involved in kidney function and RNA modifications. The identification and exploration of RNA modification-related single-nucleotide polymorphisms (RNAm-SNPs) associated with kidney function can help us to comprehensively understand the underlying mechanism of kidney disease and identify potential therapeutic targets.

Methods

First, we examined the association of RNAm-SNPs with eGFR. Second, we performed expression quanti

SUBMITTER: Liu X 

PROVIDER: S-EPMC11538735 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature