Identification of key signaling pathways and novel computational drug target for oral cancer, metabolic disorders and periodontal disease.

ABSTRACT:

Aim

Due to conventional endocrinological methods, there is presently no shared work available, and no therapeutic options have been demonstrated in oral cancer (OC) and periodontal disease (PD), type 2 diabetes (T2D), and obese patients. The aim of this study is to determine the similar molecular pathways and potential therapeutic targets in PD, OC, T2D, and obesity that may be used to anticipate the progression of the disease.

Methods

Four Gene Expression Omnibus (GEO) microarray datasets (GSE29221, GSE15773, GSE16134, and GSE13601) are used for finding differentially expressed genes (DEGs) for T2D, obese, and PD patients with OC in order to explore comparable pathways and therapeutic medications. Gene ontology (GO) and pathway analysis were used to investigate the function

SUBMITTER: Alam MK 

PROVIDER: S-EPMC11539153 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature