Detection of cefiderocol and aztreonam/avibactam resistance in epidemic <i>Escherichia coli</i> ST-361 carrying <i>bla</i><sub>NDM-5</sub> and <i>bla</i><sub>KPC-3</sub> from foreign fighters evacuated from Ukraine.
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ABSTRACT: Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying blaNDM-5, blaKPC-3, blaCTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the blaCMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.
SUBMITTER: Martin MJ
PROVIDER: S-EPMC11539215 | biostudies-literature | 2024 Nov
REPOSITORIES: biostudies-literature
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