The point mutation A1387G in the 16S rRNA gene confers aminoglycoside resistance in <i>Campylobacter jejuni</i> and <i>Campylobacter coli</i>.

ABSTRACT: Thermotolerant Campylobacter spp. are the most frequent cause of foodborne bacterial diarrhea and high-priority antibiotic-resistant pathogens, according to the World Health Organization (WHO). Monitoring revealed current low prevalence of gentamicin resistance in European Campylobacter spp. isolates but substantial presence of gentamicin modifying genes circulating globally. Using a combined approach of natural transformation and whole-genome sequencing, we revealed a novel gentamicin resistance mechanism, namely the point mutation A1387G in the 16S rRNA gene, originally identified in a C. coli isolate from turkey caecal content. The transformation rate of the resistance using genomic DNA of the resistant donor to sensitive recipient C. jejuni and C. coli

SUBMITTER: Zarske M 

PROVIDER: S-EPMC11539217 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature