Overexpression of β-lactamase genes (<i>bla</i>_KPC, <i>bla</i>_SHV) and novel CirA deficiencies contribute to decreased cefiderocol susceptibility in carbapenem-resistant <i>Klebsiella pneumoniae</i> before its approval in China.

ABSTRACT: Cefiderocol (FDC) is an effective antibiotic that is used to treat severe infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). The mechanisms underlying FDC resistance and molecular epidemiology in China remain unclear. We collected 477 non-duplicate CRKP clinical isolates in central China and characterized their susceptibility to FDC, virulence genes, and sequence typing. The overall FDC susceptibility rate of CRKP was 99.2% in central China, which was higher than that in North America and Europe (96.1%), with MIC_50/90 values of 1/2 mg/L. The decrease in FDC susceptibility in central China was concentrated in the ST11 CRKP-carrying virulence plasmids. Whole-genome sequencing (WGS) and quantitative reverse transcription PCR (qRT-PCR) experiments showed

SUBMITTER: Hong H 

PROVIDER: S-EPMC11539243 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature