RNAs m⁶A modification facilitates UVB-induced photoaging.

ABSTRACT: RNA N6-methylation (m⁶A) modification is common in eukaryotic mRNA and has been linked to various physiological disorders, including UVB-induced photoaging. To identify biological differences among photoaging. Three pairs of normal and photoaged skin tissues were collected for m⁶A RNA sequencing assay. Transcriptome profiles showed differential m⁶A methylation modifications in 1365 mRNAs in photoaging skin tissues. Pathway analysis revealed the involvement of cellular stress response and regulation of cell cycle G2/M phase transition in m⁶A-mRNAs. Further experiments validated the differential expression of m⁶A methyltransferases (METTL3 and METTL14) and hypermethylation modification in mRNAs (CENPE, PPM1B and TPM1). In vitro st

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11539279 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature