Breast cancer cells utilize T3 to trigger proliferation through cellular Ca²⁺ modulation.

ABSTRACT: High levels of thyroid hormones are linked to increased risk and advanced stages of breast cancer. Our previous work demonstrated that the biologically active triiodothyronine (T3) facilitates mitochondrial ATP production by upregulating Ca²⁺ handling proteins, thereby boosting mitochondrial Ca²⁺ uptake and Krebs cycle activity. In this study, different cell types were utilized to investigate whether T3 activates a Ca²⁺-induced signaling pathway to boost cancer cell proliferation. Using live-cell imaging, biochemical assays, and molecular profiling, differences in intracellular signaling among MCF7 and MDA-MB-468 breast cancer cells, non-cancerous breast cells hTERT-HME1, and PC3 prostate carcinoma cells, previously found to be insensitive to thyroid hormon

SUBMITTER: Tawfik I 

PROVIDER: S-EPMC11539297 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature