Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids.

ABSTRACT:

Background

Chronic ethanol exposure (CEE) is recognized as an important risk factor for depression, and the gut-brain axis has emerged as a key mechanism underlying chronic ethanol exposure-induced anxiety and depression-like behaviors. Short-chain fatty acids (SCFAs), which are the key metabolites generated by gut microbiota from insoluble dietary fiber, exert protective roles on the central nervous system, including the reduction of neuroinflammation. However, the link between gut microbial disturbances caused by chronic ethanol exposure, production of SCFAs, and anxiety and depression-like behaviors remains unclear.

Methods

Initially, a 90-day chronic ethanol exposure model was established, followed by fecal microbiota transplantation model, which was supplemented with SC

SUBMITTER: Shen H 

PROVIDER: S-EPMC11539449 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature