Are viral loads in the febrile phase a predictive factor of dengue disease severity?

ABSTRACT:

Background

As many studies have shown conflicting results regarding the extent of viraemia and clinical disease severity, we sought to investigate if viraemia during early dengue illness is associated with subsequent clinical disease severity.

Methods

Realtime PCR was carried out to identify the dengue virus (DENV serotype), in 362 patients, presenting within the first 4 days of illness, from 2017 to 2022, in Colombo Sri Lanka. To characterize subsequent clinical disease severity, all patients were followed throughout their illness daily and disease severity classified according to WHO 1997 and 2009 disease classification.

Results

263 patients had DF, 99 progressed to develop DHF, and 15/99 with DHF developed shock (DSS). Although the viral loads were higher in the fe

SUBMITTER: Dayarathna S 

PROVIDER: S-EPMC11539692 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature