Dissecting L-glutamine metabolism in acute myeloid leukemia: single-cell insights and therapeutic implications.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a rapidly progressing blood cancer. The prognosis of AML can be challenging, emphasizing the need for ongoing research and innovative approaches to improve outcomes in individuals affected by this formidable hematologic malignancy.

Methods

In this study, we used single-cell RNA sequencing (scRNA-seq) from AML patients to investigate the impact of L-glutamine metabolism-related genes on disease progression.

Results

Our analysis revealed increased glutamine-related activity in CD34 + pre-B cells, suggesting a potential regulatory role in tumorigenesis and AML progression. Furthermore, intercellular communication analysis revealed a significant signaling pathway involving macrophage migration inhibitory factor signaling through

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11539756 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature