The medial entorhinal cortex encodes multisensory spatial information.

ABSTRACT: Animals employ spatial information in multisensory modalities to navigate their natural environments. However, it is unclear whether the brain encodes such information in separate cognitive maps or integrates it all into a single, universal map. We address this question in the microcircuit of the medial entorhinal cortex (MEC), a cognitive map of space. Using cellular-resolution calcium imaging, we examine the MEC of mice navigating virtual reality tracks, where visual and auditory cues provide comparable spatial information. We uncover two cell types: "unimodality cells" and "multimodality cells." The unimodality cells specifically represent either auditory or visual spatial information. They are anatomically intermingled and maintain sensory preferences across multiple tracks and behavio

SUBMITTER: Nguyen D 

PROVIDER: S-EPMC11539853 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature