Direct Imaging of Radiation-Sensitive Organic Polymer-Based Nanocrystals at Sub-Angstrom Resolution.

ABSTRACT: Seeing the atomic configuration of single organic nanoparticles at a sub-Šspatial resolution by transmission electron microscopy has been so far prevented by the high sensitivity of soft matter to radiation damage. This difficulty is related to the need to irradiate the particle with a total dose of a few electrons/Ų, not compatible with the electron beam density necessary to search the low-contrast nanoparticle, to control its drift, finely adjust the electron-optical conditions and particle orientation, and finally acquire an effective atomic-resolution image. On the other hand, the capability to study individual pristine nanoparticles, such as proteins, active pharmaceutical ingredients, and polymers, with peculiar sensitivity to the variation in the local structure, defect

SUBMITTER: Carlino E 

PROVIDER: S-EPMC11539949 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature