Quantitative MRI biomarker for classification of clinically significant prostate cancer: Calibration for reproducibility across echo times.

ABSTRACT:

Purpose

The purpose of the present study is to develop a calibration method to account for differences in echo times (TE) and facilitate the use of restriction spectrum imaging restriction score (RSIrs) as a quantitative biomarker for the detection of clinically significant prostate cancer (csPCa).

Methods

This study included 197 consecutive patients who underwent MRI and biopsy examination; 97 were diagnosed with csPCa (grade group ≥ 2). RSI data were acquired three times during the same session: twice at minimum TE ~75 ms and once at TE = 90 ms (TEmin₁, TEmin₂, and TE90, respectively). A linear regression model was determined to match the C-maps of TE90 to the reference C-maps of TEmin₁ within the interval ranging from 95th to 99th percenti

SUBMITTER: Kallis K 

PROVIDER: S-EPMC11539966 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature