Retinal Function in Advanced Multiple Sclerosis.

ABSTRACT:

Purpose

People with multiple sclerosis (pwMS) experience autoimmunity-mediated inflammation and neurodegeneration throughout the central nervous system. There remains a need for clinically accessible, reliable functional markers of neurodegeneration in MS. Previous research has described changes to electroretinography (ERG)-derived measures of retinal bipolar cell function in pwMS early in the disease course. We, therefore, investigated ERG as a potential outcome measure in individuals with more advanced disease.

Methods

This cross-sectional observational study included pwMS with Expanded Disability Status Scale (EDSS) scores of ≥3.0 and healthy control (HC) participants who underwent ERG, optical coherence tomography, high- and low-contrast visual acuity measurement, and an

SUBMITTER: Hanson JVM 

PROVIDER: S-EPMC11539974 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature