Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis.

ABSTRACT:

Purpose

Endophthalmitis is a severe inflammatory condition due to intraocular infections that often leads to irreversible blindness. This study aimed to understand the age-dependent metabolic alterations in the vitreous of patients with bacterial endophthalmitis.

Methods

The study included the vitreous metabolome of patients with bacterial endophthalmitis (group 1, n = 15) and uninfected controls (group 2, n = 14), which were further stratified into three groups according to their age: young (0-30 years), middle (31-60 years), and elderly (>60 years). Vitreous samples were subjected to untargeted metabolomic analysis using high-resolution mass spectrometry (HRMS)m and acquired mass spectrometry data were analyzed using MetaboAnalyst 6.0. The altered metabolites with log2FC o

SUBMITTER: Maiti S 

PROVIDER: S-EPMC11540026 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature