Comparison of Geographic Atrophy Measurements Between Blue-Light Heidelberg Standard Field and Green-Light Optos Ultrawide Field Autofluorescence.

ABSTRACT:

Purpose

This study compared geographic atrophy (GA) measurements in the macula using standard 30° field and ultrawide field (UWF) fundus autofluorescence (FAF) imaging.

Methods

Participants from Age-Related Eye Disease Study 2 (AREDS2) and Optos PEripheral RetinA (OPERA) studies with GA were included for comparison between standard field FAF with Heidelberg Spectralis and Optos 200Tx UWF FAF. Two time points 5 years apart were evaluated. GA area (mm2) was recorded in the macular area for both imaging types and in the peripheral field for UWF.

Results

Of 102 paired images (73 subjects), the mean (SD) baseline GA area was 5.32 (6.36) mm2 with standard and 4.79 (5.87) mm2 with UWF FAF (P < 0.001). The mean difference between the two modalities was 0.52 mm2 (95% confidenc

SUBMITTER: Froines CP 

PROVIDER: S-EPMC11540041 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature