Free-water: A promising structural biomarker for cognitive decline in aging and mild cognitive impairment.

ABSTRACT: Diffusion MRI derived free-water (FW) metrics show promise in predicting cognitive impairment and decline in aging and Alzheimer's disease (AD). FW is sensitive to subtle changes in brain microstructure, so it is possible these measures may be more sensitive than traditional structural neuroimaging biomarkers. In this study, we examined the associations among FW metrics (measured in the hippocampus and two AD signature meta-ROIs) with cognitive performance, and compared FW findings to those from more traditional neuroimaging biomarkers of AD. We leveraged data from a longitudinal cohort (n_participants = 296, n_observations = 870, age at baseline: 73 ± 7 years, 40% mild cognitive impairment [MCI]) of older adults who underwent serial neuropsychological assessment (episo

SUBMITTER: Sathe A 

PROVIDER: S-EPMC11540062 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature