Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice.

ABSTRACT: Probiotics hold great potential for treating metabolic diseases such as obesity. Given the complex and multifactorial nature of these diseases, research on probiotic combination with multiple targets has become popular. Here, we choose four obesity-related targets to perform high-throughput screening, including pancreatic lipase activity, bile salt hydrolase activity, glucagon-like peptide-1 secretion and adipocyte differentiation. Then, we obtained 649 multi-strain combinations with the requirement that each must cover all these targets in principle. After in vitro co-culture and in vivo co-colonization experiments, only four (<0.7%) combinations were selected as symbiotic probiotic communities (SPCs). Next, genome-scale metabolic model analysis revealed that these SPCs show

SUBMITTER: Guo D 

PROVIDER: S-EPMC11540072 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature