Faecal (or intestinal) microbiota transplant: a tool for repairing the gut microbiome.

ABSTRACT: Faecal/intestinal microbiota transplant (FMT/IMT) is an efficacious treatment option for recurrent Clostridioides difficile infection, which has prompted substantial interest in FMT's potential role in the management of a much broader range of diseases associated with the gut microbiome. Despite its promise, the success rates of FMT in these other settings have been variable. This review critically evaluates the current evidence on the impact of clinical, biological, and procedural factors upon the therapeutic efficacy of FMT, and identifies areas that remain nebulous. Due to some of these factors, the optimal therapeutic approach remains unclear; for example, the preferred timing of FMT administration in a heavily antibiotic-exposed hematopoietic cell transplant recipient is not st

SUBMITTER: Ghani R 

PROVIDER: S-EPMC11540080 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature