TM4SF4 is a diagnostic biomarker accelerating progression of papillary thyroid cancer via AKT pathway.

ABSTRACT: The incidence of papillary thyroid cancer (PTC) has been steadily rising, though the underlying mechanism remains unclear. This study aims to elucidate the biological role of TM4SF4 in the PTC progression. Our differential expression analysis indicated that TM4SF4 was significantly upregulated in PTC, which was corroborated in both our local cohort and the data from Human Protein Atlas. Additionally, clinical characteristics analysis and receiver operating characteristic curves (ROC) demonstrated that TM4SF4 served as a significant diagnostic marker for PTC. Correlation and enrichment analysis of TM4SF4-related partners suggested that it was involved in cell junction and cohesion processes. Furthermore, immune infiltration analysis revealed a positive correlation between TM4SF4 expression

SUBMITTER: Lin L 

PROVIDER: S-EPMC11540099 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature