Protein Corona Formation on Cadmium-Bearing Nanoparticles: Important Role of Facet-Dependent Binding of Cysteine-Rich Proteins.

ABSTRACT: Cadmium-bearing nanoparticles, such as nanoparticulate cadmium selenide (CdSe) and cadmium sulfide (CdS), widely exist in the environment and originate from both natural and anthropogenic sources. Risk assessment of these nanoparticles cannot be accurate without taking into account the properties of the protein corona that is acquired by the nanoparticles upon biouptake. Here, we show that the compositions of the protein corona on CdSe/CdS nanoparticles are regulated collectively by the surface atomic arrangement of the nanoparticles and the abundance and distribution of cysteine moieties of the proteins in contact with the nanoparticles. A proteomic analysis shows that the observed facet-dependent preferential binding of proteins is mostly related to the cysteine contents of the proteins,

SUBMITTER: Qi Y 

PROVIDER: S-EPMC11540113 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature