Prenatal Environmental Antibiotic Exposure and Autism Spectrum Disorder Symptoms in Children at 3 Years of Age: Findings from the Ma'anshan Birth Cohort Study.

ABSTRACT: Antibiotic exposure during pregnancy may affect the neurodevelopment of children, but biomonitoring-based population studies on this class of new pollutants are lacking. We conducted a prospective birth cohort study of 2860 mother-child pairs, measured the urinary concentrations of 41 antibiotics and their two metabolites over three trimesters, and assessed children's autism spectrum disorder (ASD) symptoms at 3 years of age. We examined the associations between prenatal antibiotic exposure and children's ASD symptoms. The least absolute shrinkage and selection operator regression screened for Tetracycline and Ofloxacin as important predictors of ASD symptoms. Modified Poisson regression models revealed that maternal Tetracycline exposure throughout pregnancy increased the risk of ASD symp

SUBMITTER: Wang B 

PROVIDER: S-EPMC11540118 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature