Sialic acid and PirB are not required for targeting of neural circuits by neurotropic mammalian orthoreovirus.

ABSTRACT: Serotype 3 (T3) strains of mammalian orthoreovirus (reovirus) spread to the central nervous system to infect the brain and cause lethal encephalitis in newborn mice. Although reovirus targets several regions in the brain, susceptibility to infection is not uniformly distributed. The neuronal subtypes and anatomic sites targeted throughout the brain are not precisely known. Reovirus binds several attachment factors and entry receptors, including sialic acid (SA)-containing glycans and paired immunoglobulin-like receptor B (PirB). While these receptors are not required for infection of some types of neurons, reovirus engagement of these receptors can influence neuronal infection in certain contexts. To identify patterns of T3 neurotropism, we used microbial identification after passive tissu

SUBMITTER: Griswold KA 

PROVIDER: S-EPMC11540169 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature