Pangenome graph analysis reveals extensive effector copy-number variation in spinach downy mildew.

ABSTRACT: Plant pathogens adapt at speeds that challenge contemporary disease management strategies like the deployment of disease resistance genes. The strong evolutionary pressure to adapt, shapes pathogens' genomes, and comparative genomics has been instrumental in characterizing this process. With the aim to capture genomic variation at high resolution and study the processes contributing to adaptation, we here leverage an innovative, multi-genome method to construct and annotate the first pangenome graph of an oomycete plant pathogen. We expand on this approach by analysing the graph and creating synteny based single-copy orthogroups for all genes. We generated telomere-to-telomere genome assemblies of six genetically diverse isolates of the oomycete pathogen Peronospora effusa, the economicall

SUBMITTER: Skiadas P 

PROVIDER: S-EPMC11540230 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature