KCTD17-mediated Ras stabilization promotes hepatocellular carcinoma progression.

ABSTRACT:

Background/aims

Potassium channel tetramerization domain containing 17 (KCTD17) protein, an adaptor for the cullin3 (Cul3) ubiquitin ligase complex, has been implicated in various human diseases; however, its role in hepatocellular carcinoma (HCC) remains elusive. Here, we aimed to elucidate the clinical features of KCTD17, and investigate the mechanisms by which KCTD17 affects HCC progression.

Methods

We analyzed transcriptomic data from patients with HCC. Hepatocyte-specific KCTD17 deficient mice were treated with diethylnitrosamine (DEN) to assess its effect on HCC progression. Additionally, we tested KCTD17-directed antisense oligonucleotides for their therapeutic potential in vivo.

Results

Our investigation revealed the upregulation of KCTD17 expression in both t

SUBMITTER: Jung YH 

PROVIDER: S-EPMC11540369 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature