Development and validation of a stromal-immune signature to predict prognosis in intrahepatic cholangiocarcinoma.

ABSTRACT:

Backgrounds/aims

Intrahepatic cholangiocarcinoma (ICC) is a highly desmoplastic tumor with poor prognosis even after curative resection. We investigated the associations between the composition of the ICC stroma and immune cell infiltration and aimed to develop a stromal-immune signature to predict prognosis in surgically treated ICC.

Methods

We recruited 359 ICC patients and performed immunohistochemistry to detect α-smooth muscle actin (α-SMA), CD3, CD4, CD8, Foxp3, CD68, and CD66b. Aniline was used to stain collagen deposition. Survival analyses were performed to detect prognostic values of these markers. Recursive partitioning for a discrete-time survival tree was applied to define a stromal-immune signature with distinct prognostic value. We delineated an integrated str

SUBMITTER: Ye YH 

PROVIDER: S-EPMC11540385 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature