Non-linear association between liver fibrosis scores and viral load in patients with chronic hepatitis B.

ABSTRACT:

Background/aims

Serum hepatitis B virus (HBV) DNA levels and non-invasive liver fibrosis scores are significantly associated with hepatocellular carcinoma (HCC) risk in chronic hepatitis B (CHB) patients. Nonetheless, the relationship between HBV DNA levels and liver fibrosis scores is unclear.

Methods

A historical cohort comprising 6,949 non-cirrhotic Korean CHB patients without significant alanine aminotransferase elevation was investigated. The association of HBV DNA levels with the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis (FIB)-4 score at baseline was analyzed using general linear models.

Results

In HBeAg-negative patients (n=4,868), HBV DNA levels correlated linearly with both APRI and FIB-4 scores. In contrast, in HBeAg-positive pat

SUBMITTER: Kim GA 

PROVIDER: S-EPMC11540400 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature