Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten.

ABSTRACT:

Introduction

The prevalence of gluten-related disorders, mainly celiac disease (CD) and non-celiac gluten sensitivity (NCGS), varies between 0.6% and 13% in the general population. There is controversial evidence regarding the association of both CD and NCGS with extra-digestive manifestations, including recurrent reproductive failure (RRF), which may have clinical implications.

Objective

To study the prevalence of HLA susceptibility alleles for CD/NCGS in a cohort of female patients with RRF from a single reference center and to evaluate the effect of a gluten-free diet on reproductive success.

Material and methods

A retrospective study was conducted on 173 patients with RRF, consecutively attended at the Reproductive Immunology Unit of San Carlos University Clinical

SUBMITTER: de la Fuente-Munoz E 

PROVIDER: S-EPMC11540631 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature