Epstein-Barr virus-specific T-cell response in pediatric liver transplant recipients: a cross-sectional study by multiparametric flow cytometry.

ABSTRACT:

Background

Epstein-Barr virus (EBV) specific T-cell response measurement can help adjust immunosuppression in transplant patients with persistent infections. We aim to define T-cell responses against EBV in a cohort of pediatric liver-transplant patients.

Methods

Thirty-eight immunosuppressed pediatric liver-transplant patients (IP) and 25 EBV-seropositive healthy-adult controls (HC) were included in our cross-sectional study. Based on their EBV serological (S) and viral load (VL) status, patients were categorized into IP-S^NEG, IP-S^POSVL^NEG and IP-S^POSVL^POS groups. T-cell response was assessed at two timepoints by stimulating cells with EBV peptides (PepTivator^®) and performing intracellular-cytokine and activ

SUBMITTER: Cuesta-Martin de la Camara R 

PROVIDER: S-EPMC11540634 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature