In utero nicotine exposure affects murine palate development.

ABSTRACT:

Objectives

Despite data linking smoking to increased risk of fetal morbidity and mortality, 11% of pregnant women continue to smoke or use alternative nicotine products. Studies confirm that nicotine exposure during pregnancy increases the incidence of birth defects; however, little research has focused on specific anatomic areas based on timing of exposure. We aim to determine critical in utero and postnatal periods of nicotine exposure that affect craniofacial development, specifically palate growth. Malformation of the palatal structures can result in numerous complications including facial growth disturbance, or impeding airway function. We hypothesized that both in utero and postnatal nicotine exposure will alter palate development.

Materials and methods

We administered

SUBMITTER: Vyas H 

PROVIDER: S-EPMC11540726 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature