Impact of nitric oxide donors on capsule, biofilm and resistance profiles of Klebsiella pneumoniae.

ABSTRACT: Klebsiella pneumoniae is considered to be a critical public health threat due to its ability to cause fatal, multi-drug-resistant infections in the bloodstream and key organs. The polysaccharide-based capsule layer that shields K. pneumoniae from clearance via innate immunity is a prominent virulence factor. K. pneumoniae also forms biofilms on biotic and abiotic surfaces. These biofilms significantly reduce penetration by, and antibacterial activity from, traditional antibiotics. Nitric oxide (NO), an endogenous molecule involved in the innate immune system, is equally effective at eradicating bacteria but without engendering resistance. This study investigated the effects of NO-releasing small molecules capable of diverse release kinetics on the capsule and biofilm formation characterist

SUBMITTER: Nguyen HK 

PROVIDER: S-EPMC11540743 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature