Whole genome sequencing distinguishes skin colonizing from infection-associated Cutibacterium acnes isolates.

ABSTRACT:

Introduction

Cutibacterium acnes can both be a helpful colonizer of the human skin as well as the causative agent of acne and purulent infections. Until today, it is a moot point whether there are C. acnes strains exclusively devoted to be part of the skin microbiome and others, that carry special features enabling them to cause disease. So far, the search for the molecular background of such diverse behavior has led to inconsistent results.

Methods

In the present study, we prospectively collected C. acnes strains from 27 infected persons and 18 healthy controls employing rigid selection criteria to ensure their role as infectious agent or colonizer. The genome sequences from these strains were obtained and carefully controlled for quality.

Results

SUBMITTER: Podbielski A 

PROVIDER: S-EPMC11540793 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature