Virome analysis provides new insights into the pathogenesis mechanism and treatment of SLE disease.

ABSTRACT:

Introduction

This study aimed to investigate the virome diversity of the SLE disease and the association between viral infections and the disease.

Methods

SLE-related RNA-Seq data were retrieved from public databases. A rigorous computational workflow was employed to identify the human viruses. Differential expression analysis and functional enrichment analysis were conducted in R.

Results

We identified ten human virus species from 826 RNA-Seq samples of human blood, comprising 688 SLE patients and 138 healthy controls. Eight of the ten virus species exhibited higher positive rates in SLE patients compared to healthy controls, with Human betaherpesvirus 5 (HHV5) having the highest positive rate (4.1%) and being exclusively detected in SLE samples. The virus abundances

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11540821 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature