Human hippocampal and entorhinal neurons encode the temporal structure of experience.

ABSTRACT: Extracting the underlying temporal structure of experience is a fundamental aspect of learning and memory that allows us to predict what is likely to happen next. Current knowledge about the neural underpinnings of this cognitive process in humans stems from functional neuroimaging research^1-5. As these methods lack direct access to the neuronal level, it remains unknown how this process is computed by neurons in the human brain. Here we record from single neurons in individuals who have been implanted with intracranial electrodes for clinical reasons, and show that human hippocampal and entorhinal neurons gradually modify their activity to encode the temporal structure of a complex image presentation sequence. This representation was formed rapidly, without providing specific i

SUBMITTER: Tacikowski P 

PROVIDER: S-EPMC11540853 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature