Coordinated inheritance of extrachromosomal DNAs in cancer cells.

ABSTRACT: The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently¹. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell division^2,3. Distinct ecDNA sequences, termed ecDNA species, can co-exist to facilitate intermolecular cooperation in cancer cells⁴. How multiple ecDNA species within a tumour cell are assorted and maintained across somatic cell generations is unclear. Here we show that cooperative ecDNA species are coordinately inherited through mitotic co-segregation. Imaging and single-cell analyses show that multiple ecDNAs encodi

SUBMITTER: Hung KL 

PROVIDER: S-EPMC11541006 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature