Pan-Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System.

ABSTRACT:

Background

The cumulative, health system-wide survival benefit of immune checkpoint inhibitors (ICIs) is unclear, particularly among real-world patients with limited life expectancies and among subgroups poorly represented on clinical trials. We sought to determine the health system-wide survival impact of ICIs.

Methods

We identified all patients receiving PD-1/PD-L1 or CTLA-4 inhibitors from 2010 to 2023 in the national Veterans Health Administration (VHA) system (ICI cohort) and all patients who received non-ICI systemic therapy in the years before ICI approval (historical control). ICI and historical control cohorts were matched on multiple cancer-related prognostic factors, comorbidities, and demographics. The effect of ICI on overall survival was quantified with Cox reg

SUBMITTER: Miller SR 

PROVIDER: S-EPMC11541111 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature