The genetic landscape of substance use disorders.

ABSTRACT: Substance use disorders represent a significant public health concern with considerable socioeconomic implications worldwide. Twin and family-based studies have long established a heritable component underlying these disorders. In recent years, genome-wide association studies of large, broadly phenotyped samples have identified regions of the genome that harbour genetic risk variants associated with substance use disorders. These regions have enabled the discovery of putative causal genes and improved our understanding of genetic relationships among substance use disorders and other traits. Furthermore, the integration of these data with clinical information has yielded promising insights into how individuals respond to medications, allowing for the development of personalized treatment ap

SUBMITTER: Gerring ZF 

PROVIDER: S-EPMC11541208 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature