Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936.

ABSTRACT: Neighbourhood disadvantage may be associated with brain health but the importance of exposure at different stages of the life course is poorly understood. Utilising the Lothian Birth Cohort 1936, we explored the relationship between residential neighbourhood deprivation from birth to late adulthood, and global and local neuroimaging measures at age 73. A total of 689 participants had at least one valid brain measures (53% male); to maximise the sample size structural equation models with full information maximum likelihood were conducted. Residing in disadvantaged neighbourhoods in mid- to late adulthood was associated with smaller total brain (β = -0.06; SE = 0.02; sample size[N] = 658; number of pairwise complete observations[n]=390), grey matter (β = -0.11; SE = 0.03; N = 658; n = 390),

SUBMITTER: Baranyi G 

PROVIDER: S-EPMC11541210 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature