Impact of MTHFD2 Expression in Bladder/Breast Cancer and Screening of Its Potential Inhibitor.

ABSTRACT: Genes of folate-mediated 1 carbon metabolism are found to be highly upregulated in tumor cells and promote cancer cell proliferation. The current study aimed to determine the expression of the MTHFD2 gene in bladder and breast cancers. Furthermore, the determination of potential ligand-based inhibitors against MTHFD2 was performed in comparison with those of chemotherapeutic drugs and natural plant-based compounds. Semiquantitative expression analysis along with structure-based virtual ligand library screening was done to find plausible inhibitors. MTHFD2 expression was significantly increased with tumor stage progression both in low- and high-grade bladder cancer and especially in triple-negative breast cancer. Virtual ligand-based library screening against the three-dimensional MTHFD2 pr

SUBMITTER: Aruge S 

PROVIDER: S-EPMC11541529 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature