The effect of prescription and over-the-counter medications on core temperature in adults during heat stress: a systematic review and meta-analysis.

ABSTRACT:

Background

Heat stress impacts are an escalating global health concern. Public health bodies such as the World Health Organization (WHO) warn that certain medications impair thermoregulation, with limited supporting evidence. Our aim was to investigate whether medications listed by the WHO increase core temperature responses during heat stress.

Methods

For this systematic review and meta-analysis, MEDLINE, PubMed, Scopus, CINAHL, Web of Science, and EMBASE were searched up to Jan.30, 2024. Randomised studies exposing humans to exertional and/or passive heat stress that investigated a drug identified by WHO compared to no drug/placebo were eligible. The primary outcome was core temperature (e.g., rectal, oesophageal, aural, tympanic). We assessed risk of bias (Cochrane's Risk

SUBMITTER: Hospers L 

PROVIDER: S-EPMC11541675 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature