Neuroinflammation, Stress-Related Suicidal Ideation, and Negative Mood in Depression.

ABSTRACT:

Importance

Brain translocator protein 18k Da (TSPO) binding, a putative marker of neuroinflammatory processes (eg, gliosis), is associated with stress and elevated in depressed and suicidal populations. However, it is unclear whether neuroinflammation moderates the impact of daily life stress on suicidal ideation and negative affect, thereby increasing risk for suicidal behavior.

Objective

To examine the association of TSPO binding in participants with depression with real-world daily experiences of acute stress-related suicidal ideation and negative affect, as well as history of suicidal behavior and clinician-rated suicidal ideation.

Design, setting, and participants

Data for this cross-sectional study were collected from June 2019 through July 2023. Procedures were

SUBMITTER: Herzog S 

PROVIDER: S-EPMC11541744 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature