Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.

ABSTRACT:

Importance

Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between AS and CAD.

Objective

To identify genetic risk loci and cardiovascular risk factors with AS-specific associations.

Design, setting, and participants

This was a genomewide association study (GWAS) of AS adjusted for CAD with participants from the European Consortium for the Genetics of Aortic Stenosis (EGAS) (recruited 2000-2020), UK Biobank (recruited 2006-2010), Estonian Biobank (recruited 1997-2019), and FinnGen (recruited 1964-2019). EGAS participants were collected from 7 sites across Europe. All participants were of European ancestry, and information on com

SUBMITTER: Trenkwalder T 

PROVIDER: S-EPMC11541746 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature