Reversal of tyrosine-linked ADP-ribosylation by ARH3 and PARG.

ABSTRACT: ADP-ribosylation is an ancient posttranslational modification with exceptional versatility in terms of breadth of modification targets including at least seven different amino acid side chains, various moieties on nucleic acids, and a variety of small chemical compounds. The spatiotemporal signaling dynamic of the different modification variations is tightly regulated and depends on the writers, erases, and readers of each type. Among these, tyrosine ADP-ribosylation (Tyr-ADPr) has been consistently detected as a novel modification type, but systematic analysis of its potential physiological role, modification establishment, and reversal are still lacking. Here we present a re-analysis of recent ADP-ribosylome data and show that Tyr-ADPr sites are conserved and enriched among ribosome biog

SUBMITTER: Rack JGM 

PROVIDER: S-EPMC11541775 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature