Intraoperative hypotension during critical phases of liver transplantation and its impact on acute kidney injury: a retrospective cohort study.

ABSTRACT:

Introduction

Acute Kidney Injury (AKI) following Liver Transplantation (LT) is associated with prolonged ICU and hospital stay, increased risk of chronic renal disease, and decreased graft survival. Intraoperative hypotension is a modifiable risk factor associated with postoperative AKI. We aimed to determine in which phase of LT hypotension has the strongest association with AKI: the anhepatic or neohepatic phase.

Methods

This retrospective cohort study included adult patients undergoing LT between January 2010 and June 2022. Exclusion criteria were re-do or combined transplantations, preoperative dialysis, and early graft failure or death. Primary outcome was AKI as defined by KDIGO. Hypotension was Mean Arterial Pressure (MAP) below predefined thresholds in minutes. Risk

SUBMITTER: Bieze M 

PROVIDER: S-EPMC11541844 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature