Construction and validation of a prognostic signature based on microvascular invasion and immune-related genes in hepatocellular carcinoma.

ABSTRACT:

Background

Microvascular invasion (MVI) is an independent risk factor of poor prognosis in hepatocellular carcinoma (HCC) and can be used to guide the diagnosis and treatment of HCC. The immune system serves as an integral role in the incidence and progression of HCC. However, the molecular biology correlation between MVI and tumor immunity and the value of combining the two parameters to predict patient prognosis and HCC response to treatment remain to be evaluated.

Results

In this study, we used univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) Cox analysis to establish the MVI and immune-related gene index (MIRGPI) including eight genes. We demonstrated that the MIRGPI was an independent risk factor in predicting the prognosis

SUBMITTER: Li H 

PROVIDER: S-EPMC11541849 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature