Relationship between regional volume changes and water diffusion in fixed marmoset brains: an in vivo and ex vivo comparison.

ABSTRACT: Ex vivo studies of the brain are often employed as experimental systems in neuroscience. In general, brains for ex vivo MRI studies are usually fixed with paraformaldehyde to preserve molecular structure and prevent tissue destruction during long-term storage. As a result, fixing brain tissue causes microstructural changes and a decrease in brain volume. Therefore, the purpose of this study was to investigate the regional effect of brain volume and microstructural changes on the restricted diffusion of water molecules in the common marmoset brain using in vivo and ex vivo brains from the same individual. We used 9.4T magnetic resonance imaging and also compared the T2-weighted images and diffusion-weighted imaging (DWI) data between in vivo and ex vivo brains to investigate changes in brai

SUBMITTER: Yoshimaru D 

PROVIDER: S-EPMC11541870 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature