Mitochondrial DNA in plasma and long-term physical recovery of critically ill patients: an observational study.

ABSTRACT:

Background

Post-intensive care syndrome (PICS) poses a notable public health concern, with survivors of critical illness experiencing long-term physical, psychological, and cognitive challenges. Mitochondrial dysfunction has gained attention for its potential involvement in PICS. However, the long-term impact of mitochondrial status on patient recovery remains uncertain. A single-centre retrospective analysis was conducted in Leeuwarden, the Netherlands, between May and November 2019, within a mixed ICU survivor cohort. Patients were assessed for mitochondrial markers (mtDNA damage represented by the presence of mtDNA fragmentation and mitochondrial DNA levels evaluated by the ratio of mtDNA and nuclear DNA), clinical factors, and long-term outcomes measured by the physical functio

SUBMITTER: Galvis-Pedraza M 

PROVIDER: S-EPMC11541963 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature