Individualised prediction of chemotherapy benefit in early-onset colorectal cancer.

ABSTRACT:

Purposes

Whether patients with early-onset colorectal cancer (EOCRC) receive chemotherapy has been controversial, so our study aimed to screen patients with EOCRC who benefit from chemotherapy.

Methods

A total of 2166 EOCRC patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were divided into chemotherapy and non-chemotherapy groups, propensity score matching (PSM) was performed to balance the differences between the groups, and the Kaplan-Meier method was used to calculate the cancer-specific survival (CSS) of EOCRC patients. Multifactorial COX regression analysis was used to identify independent prognostic factors for CSS and to construct a nomogram for predicting CSS in EOCRC patients. The overall risk score was calculat

SUBMITTER: Li J 

PROVIDER: S-EPMC11541974 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature