Identification of clade-defining single nucleotide polymorphisms for improved rabies virus surveillance.

ABSTRACT:

Background

Rabies is an ancient disease that remains endemic in many countries. It causes many human deaths annually, predominantly in resource-poor countries. Over evolutionary timelines, several rabies virus (RABV) genotypes have stabilised, forming distinct clades. Extensive studies have been conducted on the origin, occurrence and spread of RABV clades. Single nucleotide polymorphisms (SNPs) distribution across the RABV genome and its clades remains largely unknown, highlighting the need for comprehensive whole-genome analyses.

Methods

We accessed whole genome sequences for RABV from public databases and identified SNPs across the whole genome sequences. Then, we annotated these SNPs using an R script, and these SNPs were categorised into different categories; universal,

SUBMITTER: Kumar A 

PROVIDER: S-EPMC11542045 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature